Not consistently, but every so often I'll hit the ESC key and have nothing happen. I can usually tap it 2-3 times and get it working again, but it happens frequently enough I wanted to report it. May be related to the bug where the camera drone won't stop (I have that one too, but clicking ESC should get me out and doesn't, just takes me to the main title screen). I was by the tent on my farm when the camera got stuck, but the ESC key lockup happens randomly throughout the game.